The Next Frontier: Engineering Magnetotheranostics for Magnetic Particle Imaging

讲座名称：The Next Frontier: Engineering Magnetotheranostics for Magnetic Particle Imaging

讲座人：Jeff W.M. Bulte 教授

讲座时间：9月12日10:00-12:00

讲座地点：会议中心104

讲座人介绍：

Jeff W.M. Bulte博士是约翰·霍普金斯大学医学院放射学、肿瘤学、生物医学工程以及化学与生物分子工程教授。他是首任科学传播放射学主任，并担任约翰·霍普金斯细胞工程研究所细胞成像主任。他是ISMRM院士及金牌获得者，WMIS、AIMBE和IAMBE院士，以及放射学研究院杰出研究员。他已发表350多篇论文和书籍章节，被引用超过4万次。他的研究方向是开发新型造影剂和纳米诊疗技术，并将其应用于分子和细胞成像，尤其侧重于体内细胞追踪和再生医学。

讲座内容：

Magnetic nanoparticles, including those formed of superparamagnetic iron oxides (SPIOs), are employed in various magnetic imaging and therapeutic techniques. In vivo imaging techniques include magnetic resonance imaging (MRI), magneto-motive ultrasonography (MMUS), magneto-photoacoustic imaging (MPAI), and magnetic particle imaging (MPI). An early example of magnetotheranostics are magnetically labeled therapeutic cells , i.e., immune cells for immunotherapy or stem cells for stem cell therapy, that can visualize their target after homing through trophic signaling, hereby also providing a diagnostic tool. More recently, the field of stem cell therapy has shifted towards “cell-free” therapy after recognizing that many of the active biomolecules are released by extracellular vesicles (EVs). Similar to their parental cells, EVs can be tracked in vivo after proper magnetic labeling, offering diagnostic information on for instance sites of inflammation in addition to exerting immunosuppresive therapeutic effects . Our lab and others have been exploring MPI to not only visualize the dynamic homing processes but also to provide quantative information using MPI “cytometry” and “EVmetry”.

A recent development in MPI-guided therapy has been the use of magnetotheranostics for magnetic fluid hyperthermia (MFH) or, when combined with gold nanoparticles, for photothermal therapy (PTT) . This has been demonstrated to be feasible not only for naked nanoparticles but also for labeled stem cells that can carry the nanoparticles towards the tumor for subsequent heating. Preclinical data indicate that the physical conditions required to heat up magnetic nanoparticles, including energy considerations, particle modifications, localization, and exposure time, can be dynamically modulated during a single treatment procedure by monitoring imaging data acquired from the same magnetic nanoparticles. This allows to selectively and precisely heat tumor locations while avoiding damage to surrounding healthy tissue, providing individualized treatment plans based on information about the biodistribution of magnetic nanoparticles within the tumor and adjacent organs, as well as the volumetric distribution of the thermal dose.

主办单位：生命科学技术学院